Is there a generic for Perphenazine?

Yes. The FDA Orange Book lists 15 approved generic (ANDA) applications for Perphenazine, referencing the brand TRILAFON. Generics rated with an "A" therapeutic-equivalence code are considered substitutable for the brand.

What is the reference-listed drug for Perphenazine?

TRILAFON (NDA 010775, SCHERING) is the reference-listed drug — the approved product a generic applicant must show its version is the same as.

What dosage forms of Perphenazine are approved?

Perphenazine is approved in the following dosage forms: concentrate, injectable, syrup, tablet, tablet, extended release.

FDA Orange Book · active-ingredient family

Perphenazine

Perphenazine: 5 brands, 15 generics; first approved Sep 10, 1987; generic available.

Generic availableHas discontinued products

Generic status & protection

Generic available — 15 ANDA applications approved.

Brands (NDA)

Generics (ANDA)

Listed patents

Presentations

Originator applications

Brand (NDA) products

TRILAFONRLD

SCHERINGNDA 010775—4 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—
4MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—
8MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—
16MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—

TRILAFON

SCHERINGNDA 011557—

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
16MG/5ML	CONCENTRATE	ORAL	Discontinued	—

TRILAFON

SCHERINGNDA 011213—

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
5MG/ML	INJECTABLE	INJECTION	Discontinued	—

TRILAFON

SCHERINGNDA 011294—

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG/5ML	SYRUP	ORAL	Discontinued	—

TRILAFON

SCHERINGNDA 011361—

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
8MG	TABLET, EXTENDED RELEASE	ORAL	Discontinued	—

Abbreviated applications

Generic (ANDA) products (15)

PERPHENAZINE

JUBILANT GENERICSANDA 21369420254 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

MACLEODS PHARMS LTDANDA 21254520244 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

APPCOANDA 21016320224 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

ZYDUS PHARMSANDA 20523220204 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

RISINGANDA 20505620194 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

MYLANANDA 20669120174 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Discontinued	—
4MG	TABLET	ORAL	Discontinued	—
8MG	TABLET	ORAL	Discontinued	—
16MG	TABLET	ORAL	Discontinued	—

PERPHENAZINE

WATSON LABS INCANDA 20758220164 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

WILSHIRE PHARMS INCANDA 20597320154 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

PHARM ASSOCANDA 0403602001

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
16MG/5ML	CONCENTRATE	ORAL	Discontinued	—

PERPHENAZINE

PH HEALTHANDA 04022619984 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
8MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

SANDOZANDA 08968519884 strengths

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
8MG	TABLET	ORAL	Rx	AB
2MG	TABLET	ORAL	Rx	AB
4MG	TABLET	ORAL	Rx	AB
16MG	TABLET	ORAL	Rx	AB

PERPHENAZINE

ANI PHARMSANDA 0897071987

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
2MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—

PERPHENAZINE

ANI PHARMSANDA 0897081987

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
4MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—

PERPHENAZINE

ANI PHARMSANDA 0894561987

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
8MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—

PERPHENAZINE

ANI PHARMSANDA 0894571987

Approved strengths under this FDA application.
Strength	Dosage form	Route	Status	TE
16MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	TABLET	ORAL	Discontinued	—

Orange Book patent file

Listed patents

No patents are listed against this product in the Orange Book. Listed patents reflect those the NDA holder submits under 21 U.S.C. 355 and are not exhaustive.

FDA approval span

Approval history

First approval

Sep 10, 1987

39 yr 5 mo ago

Most recent approval

Mar 18, 2025

1 yr 4 mo ago

Approvals span 1987–2025 across 20 FDA applications.

Brand (NDA) 525%

Generic (ANDA) 1575%

Perphenazine — frequently asked questions

Generics, reference-listed drug, patents, and exclusivity for this active ingredient, from the FDA Orange Book.

Built directly from the FDA Orange Book data file (products, patents, and exclusivity). TE codes, RLD/RS flags, patent expirations, and exclusivity dates match the official FDA record. Listed patents reflect those the NDA holder submits under 21 U.S.C. 355 and are not exhaustive.

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